Thursday, November 8, 2007

Wacker oxidation

1. PdCl2/CuCl/DMF/H2O/O2/temp
usually only for terminal alkene, methylketone is the product.

2. internal alkene is less reactive and no regioselectivity.
If the internal alkene has an allylic alcohol, product will be only bata-alcohol ketone.

3. catalytic amount of Cu(OAc)2 can be used.
this condition is less reactive, but some acid sensitive groups can be preserved, and also yield can be higher.

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