Sunday, November 25, 2007

hydrogenation opening of cyclopropane

cyclopropane is less reactive than double bond. It is possible to saturate double bond without touching cyclopropane.

PtO2/AcOH/H2
this is the general way to open the cyclopropane between the less substituted carbons.

if you run the rxn in basic or neutral solvents like MeOH will give ring opening product with less selectivity.

1 comment:

Anonymous said...

Could you please give the reference for this.