Thursday, November 15, 2007

trityl ether protection group

behaves like Bn ether.very bulky, so better selectivity towards primary alcohol.

trityl chloride, TEA, DCM

easily falled off when contact with Silica gel.(during column)
pretreat the silica gel with 1% TEA in P.E. can prevent it completely.

can be removed by hydrogenation(pd/c, H2), addition of Py can preserve it.

No comments: