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Sunday, October 28, 2007
selectivity of epoxidation by mcpba
electron rich alkene reacts first,
tri-sub alkene reacts first, then di-sub alkene.
NaHCO3 can be added to neutralize the acid generated.
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selectivity of epoxidation by mcpba
convert ketone to alkene
protection of ketone by Li enolate.
Reduction of ketone
cationic cyclization
making of beta-ketoester
HMPA
organomagnesium
organolithium reagent
Cu mediated 1,4 and 1,5 addition
cleavage of double bond to diol
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