Monday, October 8, 2007

Reduction of ketone

1. Meerwein-Ponndorf-Verley Reduction
thermodynamic alcohol is formed instead of kinetic product (compare to LAH).
Al(OR)3 ,i-prOH.
lanthanides are m
ore reactive, for example Gd.

2. LAH
solvent THF or Et2O. Exothermic, slow addition!
when quenching LAH reaction, if x gram LAH used, then add x g water, x ml of 15% NaOH in water, 3x gram of water finally. Then a easy filtering through a celite pad will remove all the metal.

3. NaBH4
reduces ketone, not ester.
solvent: MeOH/THF.

4. DIBAL-H
reduces ester to aldehyde.

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