canion effect:
Li, Na, K, Cs
C---------O
smaller canion like Li can chelate with Oxygen, so carbon is more active compared to the oxygen atom. But at the same time, both C and O are less reactive compared to bigger canion!
solvent effect:
hexane, toluene, THF, acetone, DMF, DMSO
C----------------------O
substrate is less solvated in less polar solvent.
temperature
high temp seems favor O alkylation.
leaving group
OTs, Br, I
soft leaving group favors C-alkylation.
Friday, August 31, 2007
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2 comments:
very nice. It would be beter if you could post some references.
cheers
OK,I will try.
thank you for your words.
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