Stereoelectronic Effect for the Selectivity in C−H Insertion of Alkylidene Carbenes

Stereoelectronic Effect for the Selectivity in C−H Insertion of Alkylidene Carbenes and Its Application to the Synthesis of Platensimycin

Sang Young Yun, Jun-Cheng Zheng and Daesung Lee* Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061J. Am. Chem. Soc., 2009, 131 (24), pp 8413–8415DOI: 10.1021/ja903526g


High selectivity in the insertion between two competing C-H bonds was observed and is believed to be the manifestation of a strong stereoelectronic effect of oxygen substituents.