Ruthenium-Catalyzed [2 + 2 + 2] Cocyclization of Diene-yne

J. Am. Chem. Soc., 129 (25), 7730 -7731, 2007.

Transition metal-catalyzed cyclizations are useful methods for the synthesis of carbo- and heterocycles.¹ Among them, [2 + 2 + 2] cocyclization is a unique and an atom-economical method. It has been shown that [2 + 2 + 2] cocyclization of ,-diyne and an alkyne or intramolecular cocyclization of triyne using a cobalt, rhodium, iridium, or ruthenium complex is a useful method for the synthesis of benzene derivatives.² However, there are a few reports of [2 + 2 + 2] cocyclization of enyne and an alkene or intramolecular reaction of diene-yne.
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