Tuesday, July 15, 2008

beta-alkylation of alcohols by Cp*Ir complex

Org. Lett., 7 (18), 4017 -4019, 2005.

very efficient coupling rxn.

Alcohols are one of the most basic and important classes of organic compounds because they have a wide variety of uses in industrial and laboratory chemistry. Although a huge number of methods for the synthesis of alcohols are known,12 the synthesis of a variety of alcohols having intricate structures through alkylation of simple alcohols usually requires tedious processes using many reagents. For example, -alkylation of a secondary alcohol can usually be accomplished via three-step transformations (oxidation,3 alkylation,4 and reduction2,5)

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