Friday, April 11, 2008

making of beta ketoester.

from aldehyde:
1. diazo ethylacetate + Tin (II) chloride.
2. beta-OH ester by enolate attack, then oxidize the beta-OH to ketone.
3. three carbon homologation. ex. the aldehyde attacked by deprotonated 3-Nitroproponic methyl ester, then dehydration of the alcohol to alkene , you get beta alkene beta-NO2 ester. Then replace NO2 group to -OH by radical procedure. you get beta-ketoester.

from ketone:
dimethyl carbonate +NaH/toluene or THF. reflux

from alpha,beta unsaturated ester
Na2PdCl4, t-BuOOH

2 comments:

alok said...

sir,
i want to prepare hydroxy propylated beta keto ester.can you please tell me the procedure to make it.
or if it is readily available in ythe market then what trade name is given to this product or who makes it.

thanks
alok jain
e.mail: alok@preciouselectrochem.com
mob: +91 9811257294

alok said...

sir,
i want to prepare hydroxy propylated beta keto ester.can you please tell me the procedure to make it.
or if it is readily available in ythe market then what trade name is given to this product or who makes it.

thanks
alok jain
e.mail: alok@preciouselectrochem.com
mob: +91 9811257294