Tuesday, January 1, 2008

Pd-Catalyzed alpha-Arylation of Trimethylsilyl Enol Ethers with Aryl Bromides and Chlorides

By John F. Hartwig, Angewandte Chemie International Edition, 2006, 5852-5855

1. these conditions allow the coupling of bromoarenes with functionalities that are not tolerated by the basic alkali-metal enolates.

2. Entry 3, 6 showed this method has very good regioselectivity.

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