Saturday, January 5, 2008

Diastereoselective Intermolecular Pauson-Khand Reactions of Chiral Cyclopropenes

Joesph M. Fox of University of Delaware.

1. the unusual reactivity of cyclopropenes can increase the scope and utility of intermolecular Pauson-Khand reactions.
2. The well-defined chiral environment of cyclopropenes has a powerful influence on the diastereoselectivity of the reactions
and leads to the production of a single cyclopentenone in each of the described cases.
3. The cyclopropane ring strongly influences the stereochemistry of reactions at the enone
4. the three-membered ring can subsequently be cleaved under mild conditions.

5. Notably, the types of products that are accessible via cyclopropene Pauson- Khand/reductive cleavage complement those that can be formed using directed Pauson-Khand methodology

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