current method involve hypervalence iodine to oxidize the carbamate or sulfonamates to the imidoiodo species followed by metal incorperation to do following C-H aminations.
One problem limiting the rxn scope and catalyst preformance is the the high-oxidative potencial of the hypervalenc iodine compund such as pida, pifa.
here I propose a new oxidant which is a imidoiodo compound with a bulky blocking group attached to the imine. It is a milder oxidant than the pida/pifa and with a certain sized bulky group, the oxidant might be able to exchange its iodo with a carbamte but not able to react with the metal like rhodium.
Such a setup can increase the catalyst scope and performance and also milder the rxn condition.
Showing posts with label nitrene. Show all posts
Showing posts with label nitrene. Show all posts
Friday, January 7, 2011
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