Showing posts with label nitrene. Show all posts
Showing posts with label nitrene. Show all posts

Friday, January 7, 2011

a mild alternative nitrene generation method for C-H amination

current method involve hypervalence iodine to oxidize the carbamate or sulfonamates to the imidoiodo species followed by metal incorperation to do following C-H aminations.
One problem limiting the rxn scope and catalyst preformance is the the high-oxidative potencial of the hypervalenc iodine compund such as pida, pifa.

here I propose a new oxidant which is a imidoiodo compound with a bulky blocking group attached to the imine. It is a milder oxidant than the pida/pifa and with a certain sized bulky group, the oxidant might be able to exchange its iodo with  a carbamte but not able to react with the metal like rhodium.
Such a setup can increase the catalyst scope and performance and also milder the rxn condition.