1. in a particular substrate bearing a terminal double bond at 5,6 position related to the acetal,
the following deprotection methods failed
Methods tried: results:
1. TFA/water/chloroform unknown product, aldehyde/alkene disappeared
2. I2/acetone unknown product, aldehyde/alkene disappeared
3.HCOOH, pentane unknown product, aldehyde/alkene disappeared
4. TESOTf, 2,6-lutidine no reaction
the following method is successful:
DDQ/MeCN/water rt.
Friday, October 15, 2010
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