Thursday, July 29, 2010

A proposal for englerin A synthesis

A hot molecular.
here I proposed a synthesis of Englerin A.

1. it is known we can open the epoxide from the more hindered/more stable site.

2. Single electron reduction then can form the required C-C bond and hopefully set the secondary alcohol.

The starting material can be prepared by C-H insertion. It is known to give trans fused 5,6 rings.


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