reagent: pocl3
solvent: mecn, benzene, toluene, dcm, dmpu.
temp: rt - reflux
time: several hours.
not a nice and clean reaction. usually low yielding because of the strong acidic condition.
the product imine is sometimes not stable.
some milder conditions:
1. pph3/ccl4/reflux
2. Tf2O
a nice link:
http://www.organic-chemistry.org/namedreactions/bischler-napieralski-reaction.shtm
Thursday, October 15, 2009
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