1. pd/c, hydrogenation.
known to be slow compare to benzyl ether.
acidic solvents like HCl/MeOH or AcOH was reported to give good results.
2. CAN/MeCN/water
mild condition, but works only for tertiary amine.
3. substitute the benzyl group with a carbamate, then remove the carbamate by various ways.
ex. vinyl formate ,allyl formate, trichloro ethyl formate,
4. oxidize it to benzoyl, then hydrolysis.
Tuesday, December 23, 2008
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1 comment:
N debebzylation should be better at higher temperature anf execess pdc
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