1. naphthalene/Li
liminted to nitriles which have a adjacent electron-withdrawing group.
2. LiDBB/THF
more reactive than LN.
1. addition of nitrile into LiDBB THF solution at -78C. reverse addition gave side products.
2. when making lidbb, n-BuLi was used to remove trace of water, otherwise, the concentration of lidbb is low.
who is doing this ?
Professor Scott D. Rychnovsky
Wednesday, August 13, 2008
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