reagent: pocl3
solvent: mecn, benzene, toluene, dcm, dmpu.
temp: rt - reflux
time: several hours.
not a nice and clean reaction. usually low yielding because of the strong acidic condition.
the product imine is sometimes not stable.
some milder conditions:
1. pph3/ccl4/reflux
2. Tf2O
a nice link:
http://www.organic-chemistry.org/namedreactions/bischler-napieralski-reaction.shtm
No comments:
Post a Comment
Your comments are welcome.