Stereoselective Olefin Isomerization Leading to Asymmetric Quaternary Carbon Construction

a good article by Prof. Scott Nelson, University of Pittsburgh, Org. Lett., 9 (12), 2325 -2328, 2007.

1. The olefin isomerization-Claisen rearrangement (ICR) sequence allow the transformation of an oxygen chirality into carbon chiralities.

2. this method allows adjacent quaternary-tertiary stereocenter relationships to be established with excellent diastereoselection.

3. Notice in the Figure 2, the only difference of the products are the quartary centers.